TOP1 - Wikipedia
It is a DNA topoisomerase, an enzyme that catalyzes the transient breaking and rejoining of a single strand of DNA. This gene encodes a DNA topoisomerase, an enzyme that controls and alters the …
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TOP1 Gene - GeneCards | TOP1 Protein | TOP1 Antibody
Jan 15, 2026 · TOP1 (DNA Topoisomerase I) is a Protein Coding gene. Diseases associated with TOP1 include Hematologic Cancer and Spinocerebellar Ataxia, Autosomal Recessive, With Axonal …
What are TOP1 inhibitors and how do they work?
Jun 21, 2024 · Topoisomerase I (TOP1) inhibitors represent a significant class of anticancer agents, playing a vital role in the treatment of various malignancies. By targeting the enzyme topoisomerase …
The Potential of Topoisomerase Inhibitor-Based Antibody–Drug …
Here, we review the importance of TOP1 inhibitor-based ADCs (TOP1-ADCs) in cancer therapy, the current state of knowledge regarding the design of TOP1-ADCs, and TOP1-ADCs under development.
RNA interacts with topoisomerase I to adjust DNA topology
Aug 21, 2024 · Topoisomerase I (TOP1) is an essential enzyme that relaxes DNA to prevent and dissipate torsional stress during transcription. However, the mechanisms underlying the regulation of …
Topoisomerase I inhibitors: Challenges, progress and the road ahead
Jun 5, 2022 · Topoisomerase IB (Top1), a subcategory of DNA topoisomerase enzymes is expressed much higher in several tumor cells. Therefore, modulating the activity of Top1 in tumor cells to …
TOP1 - DNA topoisomerase 1 - Homo sapiens (Human) - UniProt
Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single …
RNA interacts with topoisomerase I to adjust DNA topology
Aug 24, 2024 · Topoisomerase I (TOP1) is an essential enzyme that relaxes DNA to prevent and dissipate torsional stress during transcription. However, the mechanisms underlying the regulation of …
7150 - Gene ResultTOP1 DNA topoisomerase I [ (human)]
DNA topoisomerase I (TOP1) interacts with cyclic cGMP-AMP synthase (cGAS) to enhance the binding of cGAS to DNA. Retention of TOP1cc to cytoplasmic chromatin depends on its stabilization by the …